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Karin Scarpinato Office: COST Dean's Office Personal Web Page: http://personal.georgiasouthern.edu/~kscarpin |
Teaching
Research Interests I am interested in
DNA repair mechanisms, with particular emphasis on mismatch repair
proteins. These proteins can repair certain types of DNA damage,
but also initiate cell death when irreparable damage is encountered. We
are exploiting this unique role to develop small molecules that utilize
mismatch repair proteins to induce cell death in cancer cells. We
are further interested in the molecular events that result in the switch
between repair and cell death. For this, we are using
fluorescent imaging to determine movement of proteins within the
cell. Another project involves the determination of cancer mechanics,
i.e. the changes a cell undergoes in terms of rigidity and intracellular
viscosity, as well as the effects of which. All projects are an
interdisciplinary collaboration with biophysicists, chemists and imaging
specialists.
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